Jeanningros R
J Auton Nerv Syst. 1984 May-Jun;10(3-4):261-8. doi: 10.1016/0165-1838(84)90022-5.
This paper reports an investigation of the comparative effects of pre-absorptive and post-absorptive stimuli associated with amino acid ingestion on cat and rat lateral hypothalamic neuronal activity. Pre-absorptive signals, conveyed by the vagus nerve and originating from the small intestine while the amino acids are about to be absorbed, have been previously identified electrophysiologically in our laboratory [3]. They were found to selectively modulate the neuronal activity of some lateral hypothalamic (LHA) cells [4]. The effects of both pre-absorptive and post-absorptive signals associated with amino acid ingestion were analyzed with regard to their degree of convergence at the lateral hypothalamic level. The pre-absorptive signals consisted of either chemospecific information arising from intestinal chemoreceptors and related to the chemical nature of the ingested nutrient, or mechanical information arising from intestinal mechanoreceptors and related to distension. The post-absorptive signal consisted of a microiontophoretic application of amino acids known to selectively affect the neuronal activity of LHA amino acid-sensitive cells [15]. The convergence on these cells of the intestinal afferent amino acid-sensitive units was postulated in this study.
本文报道了一项关于与氨基酸摄入相关的吸收前和吸收后刺激对猫和大鼠下丘脑外侧神经元活动的比较影响的研究。吸收前信号由迷走神经传导，在氨基酸即将被吸收时从小肠发出，此前已在我们实验室通过电生理学方法鉴定出来[3]。研究发现它们能选择性地调节一些下丘脑外侧（LHA）细胞的神经元活动[4]。本文分析了与氨基酸摄入相关的吸收前和吸收后信号在下丘脑外侧水平的汇聚程度。吸收前信号包括来自肠道化学感受器的化学特异性信息，与摄入营养物质的化学性质有关，以及来自肠道机械感受器的机械信息，与扩张有关。吸收后信号包括通过微离子电泳施加已知能选择性影响LHA氨基酸敏感细胞神经元活动的氨基酸[15]。本研究假设肠道传入的氨基酸敏感单元会汇聚到这些细胞上。
