Jeanningros R
J Auton Nerv Syst. 1984 Jul;11(1):1-11. doi: 10.1016/0165-1838(84)90003-1.
Single unit discharges in the lateral hypothalamic area (LH) were extracellularly recorded in chloralose anesthetized cats, while gastric or intestinal distension was performed. 47 out of 95 units were sensitive to gastric distension. Both phasic or tonic increases and decreases in firing rate were observed. Out of 41 units sensitive to gastric filling, 7 were also responsive to gastric emptying, exhibiting changes in the same direction to positive and negative variation in gastric pressure. Intestinal distension elicited changes in firing rate in 15 out of 34 units tested. As during gastric distension, units decreased or increased in firing rate while distension of the lumen was performed. The latencies of responses to gastric and intestinal distension were very short (less than one second) and were consistent with the functional properties of gastrointestinal mechanoreceptors previously described. In addition, 5 out of 25 units sensitive to gastric or intestinal distension, were responsive to both gastric and intestinal distensions exhibiting changes in the same direction. In this case, vagus nerve stimulation produced the same effect as the gastro-intestinal distensions. The results are discussed in terms of convergence of gastric and intestinal mechanoreceptor inputs on lateral hypothalamic neurons, in relation to the propagation of ingested food throughout the digestive tract.
在水合氯醛麻醉的猫身上，对下丘脑外侧区（LH）的单个神经元放电进行细胞外记录，同时进行胃或肠扩张。95个神经元中有47个对胃扩张敏感。观察到放电频率的相位性或紧张性增加和减少。在41个对胃充盈敏感的神经元中，有7个对胃排空也有反应，对胃内压力的正负变化表现出相同方向的变化。在34个接受测试的神经元中，有15个对肠扩张有放电频率的变化。与胃扩张时一样，在肠腔扩张时神经元放电频率减少或增加。对胃和肠扩张的反应潜伏期非常短（不到一秒），与先前描述的胃肠道机械感受器的功能特性一致。此外，在25个对胃或肠扩张敏感的神经元中，有5个对胃和肠扩张都有反应，表现出相同方向的变化。在这种情况下，迷走神经刺激产生的效果与胃肠道扩张相同。根据胃和肠机械感受器输入在下丘脑外侧神经元上的汇聚，以及摄入食物在整个消化道中的传播，对结果进行了讨论。
