Hasegawa Y, Nakano S, Ibuka K, Hashizume T, Sasaki Y, Imaoka S, Ishiguro S, Kasugai H, Okano Y, Tanaka S
J Nucl Med. 1984 Oct;25(10):1122-6.
Concentration of Tc-99m(Sn)-N-pyridoxyl-5-methyltryptophan (Tc-99m PMT), a biliary agent, in hepatic tumors was studied with delayed hepatobiliary imaging in 23 patients with histologically verified hepatocellular carcinomas. All 23 showed filling defects on liver images obtained with Tc-99m tin colloid. In the images taken 5 hr after Tc-99m PMT injection, ten cases showed increased uptake in the carcinoma, six nearly normal uptake, and seven decreased uptake. In those showing the increased uptake of Tc-99m PMT in the tumor, the ratio of the radioactivity in the lesion to that in the adjacent liver parenchyma (T/L ratio) increased progressively with time for 5 hr after injection. These results indicate that delayed Tc-99m PMT images, obtained 5 hr after injection, are useful in assessment of uptake of the radioactivity by hepatocellular carcinoma.
用延迟肝胆显像研究了23例经组织学证实为肝细胞癌患者的肝胆显像剂锝-99m（锡）-N-吡哆醛-5-甲基色氨酸（Tc-99m PMT）在肝肿瘤中的浓度。所有23例患者用Tc-99m锡胶体获得的肝脏图像均显示充盈缺损。在注射Tc-99m PMT后5小时拍摄的图像中，10例显示癌灶摄取增加，6例摄取接近正常，7例摄取减少。在肿瘤中显示Tc-99m PMT摄取增加的患者中，病变处放射性与相邻肝实质放射性之比（T/L比）在注射后5小时内随时间逐渐增加。这些结果表明，注射后5小时获得的延迟Tc-99m PMT图像有助于评估肝细胞癌对放射性的摄取情况。
