Hasegawa Y, Nakano S, Ishiguro S, Imaoka S, Sasaki Y, Tanaka S, Kasugai H, Kojima J, Ishigami S
Department of Nuclear Medicine, Center for Adult Diseases, Osaka, Japan.
Eur J Nucl Med. 1988;14(7-8):414-8. doi: 10.1007/BF00254396.
Images were obtained both with a biliary agent, 99mTc-Sn-N-pyridoxyl-5-methyltryptophan (99mTc-PMT), and with 67Ga-citrate in 40 cases of hepatocellular carcinoma and in 43 cases of other hepatic diseases and results were compared. Positive results were obtained by delayed 99mTc-PMT imaging in 25 (63%) of 40 cases of hepatoma: the hepatic tumor showed increased uptake in 18 cases (45%) and equilibrated uptake in 7 cases (18%). Positive 67Ga-citrate imaging was found in 28 (70%) of the 40 cases of hepatoma: increased uptake was seen in 24 cases (60%) and equilibrated uptake in 4 cases (10%). Of 15 cases of hepatoma giving negative results in the 99mTc-PMT study, 7 cases (47%) took up 67Ga-citrate, and 6 of these showed increased 67Ga-citrate uptake by the hepatic tumors. A certain relation existed between the degree of histological differentiation of hepatomas and the intensity of 99mTc-PMT uptake by those tumors, while such a histological correlation was denied for 67Ga-citrate uptake by the tumors. Delayed 99mTc-PMT imaging is preferable to 67Ga-citrate imaging for increasing the specificity of diagnosis of hepatoma. 67Ga-citrate should be used in those cases that do not give positive results with 99mTc-PMT.
对40例肝细胞癌患者和43例其他肝脏疾病患者，分别使用胆系显像剂99m锝-锡-N-吡哆醛-5-甲基色氨酸（99mTc-PMT）和枸橼酸镓67Ga进行显像，并比较结果。40例肝癌患者中，延迟99mTc-PMT显像阳性者25例（63%）：肝肿瘤摄取增加者18例（45%），摄取平衡者7例（18%）。40例肝癌患者中，枸橼酸镓67Ga显像阳性者28例（70%）：摄取增加者24例（60%），摄取平衡者4例（10%）。99mTc-PMT检查结果为阴性的15例肝癌患者中，7例（47%）摄取枸橼酸镓67Ga，其中6例肝肿瘤的枸橼酸镓67Ga摄取增加。肝癌的组织学分化程度与肿瘤对99mTc-PMT的摄取强度之间存在一定关系，而肿瘤对枸橼酸镓67Ga的摄取与组织学无此相关性。为提高肝癌诊断的特异性，延迟99mTc-PMT显像优于枸橼酸镓67Ga显像。对于99mTc-PMT检查结果为阴性的病例，应使用枸橼酸镓67Ga。
