Azzopardi J G, Salm R
J Pathol. 1984 Sep;144(1):15-23. doi: 10.1002/path.1711440103.
Twenty-four cases of a solid benign tumour of breast ducts are described, for which we propose the name 'ductal adenoma'. The lesion consists of a single nodule or multiple nodules involving medium size and small ducts, but not major subareolar ducts. It presents as a palpable lump, and is not associated with a nipple discharge. Clinically, radiologically and macroscopically, it can simulate malignancy because of its occurrence in older age groups, frequent microcalcification and the firmness and irregularity of many lesions. Fibrous sclerosis sometimes results in distortion with apparent invasion of surrounding tissue. It can be mistaken for carcinoma both on frozen and paraffin sections. Differentiation into epithelial and myoepithelial cells is the most reliable criterion in the recognition of this lesion as benign. It has microscopic affinities with ductal papilloma, on the one hand, and with salivary-type adenoma, on the other. Ductal adenoma constitutes the third major type of adenoma in the breast, in addition to the already widely recognized nipple adenoma and tubular adenoma.
本文描述了24例乳腺导管实性良性肿瘤病例，我们建议将其命名为“导管腺瘤”。该病变由单个结节或多个结节组成，累及中小导管，但不累及乳晕下大导管。它表现为可触及的肿块，与乳头溢液无关。在临床、放射学和大体检查方面，由于其好发于老年人群、常见微钙化以及许多病变质地坚硬且形态不规则，它可能类似恶性肿瘤。纤维硬化有时会导致变形，看似侵犯周围组织。在冰冻切片和石蜡切片上它都可能被误诊为癌。上皮细胞和肌上皮细胞的分化是将该病变识别为良性病变的最可靠标准。它在显微镜下一方面与导管乳头状瘤有相似之处，另一方面与涎腺型腺瘤有相似之处。除了已被广泛认可的乳头腺瘤和管状腺瘤外，导管腺瘤构成了乳腺腺瘤的第三种主要类型。
