Reilly M A, Wajda I J, Banay-Schwartz M, Lajtha A
J Recept Res. 1983;3(6):703-10. doi: 10.3109/10799898309041955.
In rat, chronic lithium treatment lowered the Kd of [3H]-mepyramine in midbrain, and reduced the Bmax in midbrain and pons-medulla. Binding of [3H]flunitrazepam in cerebellum and midbrain was not altered. The suggestion that some actions of lithium may occur by way of central nervous system receptors is further supported by these observations that lithium's effects on neurotransmitter systems are regional and specific.
在大鼠中，长期锂治疗降低了中脑中[3H] - 美吡拉敏的解离常数（Kd），并降低了中脑和脑桥 - 延髓中的最大结合量（Bmax）。小脑和中脑中[3H]氟硝西泮的结合未发生改变。锂对神经递质系统的影响具有区域特异性，这些观察结果进一步支持了锂的某些作用可能通过中枢神经系统受体发生的观点。
