Nomizu T, Sekikawa K, Watanabe I, Endo S
Gan No Rinsho. 1984 Aug;30(10):1251-5.
The occurrence of breast cancer in 5 members of a family is reported. No specificity of the location, staging or histological typing of the lesions was observed in these cancers. But the characteristics of "hereditary breast cancer", early onset and the occurrence of metachronous double cancers, were observed. As for heredity, it is suspected to be autosomal dominant trait; on the other hand it is more appropriate to assume a poly genic pattern. Recognizing the importance of familial cancer occurrence, it may be possible to detect early cancerous lesions in family members.
本文报道了一个家族中5名成员患乳腺癌的情况。这些癌症在病变的位置、分期或组织学类型上未观察到特异性。但观察到了“遗传性乳腺癌”的特征，即发病早和异时性双侧癌的发生。至于遗传方式，怀疑是常染色体显性遗传特征；另一方面，假设为多基因模式可能更合适。认识到家族性癌症发生的重要性，有可能在家族成员中检测到早期癌性病变。
