Al-Jurf A S, Jochimsen P R, Shirazi S S, Zike W L, Urdaneta L F
J Surg Oncol. 1984 Oct;27(2):119-23. doi: 10.1002/jso.2930270213.
This report reviews the results of treatment of hepatic malignancies by intra-arterial infusional chemotherapy and hepatic artery ligation. Seventy-nine patients with liver metastases or primary hepatomas were treated by this technique between the years 1970 and 1982. The majority of patients had metastatic disease from colon and rectal cancers. The median and mean survivals in the total group was 10 and 14 months, respectively (including operative deaths). Patients with metastatic disease from colon and rectal cancers had better survival than those with metastases from other primaries. Patients with synchronous liver malignancy had better survival than those with metachronous disease. Length of survival correlated positively with the duration of chemotherapeutic infusions, the latter being frequently (in 42% of patients) interrupted because of catheter complications. A new technique utilizing implantable pumps can be expected to further improve the results by reducing catheter malfunction and prolonging treatment courses.
本报告回顾了经动脉灌注化疗和肝动脉结扎治疗肝恶性肿瘤的结果。1970年至1982年间，79例肝转移瘤或原发性肝癌患者接受了该技术治疗。大多数患者患有结肠癌和直肠癌的转移疾病。总组的中位生存期和平均生存期分别为10个月和14个月（包括手术死亡）。结肠癌和直肠癌转移患者的生存期优于其他原发性转移患者。同时性肝恶性肿瘤患者的生存期优于异时性疾病患者。生存期与化疗输注持续时间呈正相关，后者因导管并发症经常（42%的患者）中断。利用植入式泵的新技术有望通过减少导管故障和延长治疗疗程进一步改善治疗效果。
