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局部钴注射：一种区分突触前轴突活动与突触后神经元活动的方法。

Local cobalt injection: a method to discriminate presynaptic axonal from postsynaptic neuronal activity.

作者信息

Kretz R

出版信息

J Neurosci Methods. 1984 Jun;11(2):129-35. doi: 10.1016/0165-0270(84)90030-x.

DOI:10.1016/0165-0270(84)90030-x
PMID:6090819
Abstract

The local application of cobalt reversibly blocks the calcium channel conductance and therefore synaptic transmission. The blockage of synaptic transmission is a useful tool to discriminate between the origins of a response recorded with extracellular metal electrodes from central nervous system substructures. Incoming presynaptic fiber activity is not affected while activity from postsynaptic elements as intrinsic neurons and cell processes are blocked. In addition, local cobalt application does not change the stimulation conditions under which the system is tested.

摘要

钴的局部应用可逆地阻断钙通道电导，从而阻断突触传递。突触传递的阻断是一种有用的工具，可用于区分用细胞外金属电极从中枢神经系统亚结构记录的反应的起源。传入的突触前纤维活动不受影响，而突触后元件（如内在神经元和细胞突起）的活动则被阻断。此外，局部应用钴不会改变测试系统的刺激条件。

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