对3T3细胞的刺激会诱导原癌基因c-fos的转录。
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.
作者信息
Greenberg M E, Ziff E B
出版信息
Nature. 1984;311(5985):433-8. doi: 10.1038/311433a0.
DOI:10.1038/311433a0
PMID:6090941
Abstract
Transcription of the c-fos proto-oncogene is greatly increased within minutes of administering purified growth factors to quiescent 3T3 cells. This stimulation is the most rapid transcriptional response to peptide growth factors yet described, and implies a role for c-fos in cell-cycle control. Transformation by c-fos may result from a temporal deregulation of this control.
摘要
在向静止的3T3细胞施用纯化的生长因子后几分钟内，原癌基因c-fos的转录大幅增加。这种刺激是迄今所描述的对肽类生长因子最迅速的转录反应，这意味着c-fos在细胞周期调控中发挥作用。c-fos介导的转化可能源于这种调控的暂时失调。
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