Jacyna M R, Boyd E J, Wormsley K G
Postgrad Med J. 1984 Sep;60(707):592-6. doi: 10.1136/pgmj.60.707.592.
Four antacid preparations have been studied in a stratified, randomized, double-blind trial to evaluate criteria which determine patients' acceptance of this type of therapy. There was a considerable range of judgements about palatability, but preference was determined not only by factors such as the smell, taste, texture and after-taste of the preparation, but also by the order in which the antacids were tested and by the age and sex of the patient. The preparations also differed considerably in acid-neutralizing capacity and ability to bind bile salts, as well as cost. We conclude that individuals requiring antacid therapy should be allowed to chose from among a range of preparations, in order to maximize compliance.
在一项分层、随机、双盲试验中，对四种抗酸制剂进行了研究，以评估决定患者接受此类治疗的标准。关于适口性的判断范围相当广泛，但偏好不仅取决于制剂的气味、味道、质地和余味等因素，还取决于测试抗酸剂的顺序以及患者的年龄和性别。这些制剂在酸中和能力、结合胆汁盐的能力以及成本方面也有很大差异。我们得出结论，需要抗酸治疗的个体应被允许从一系列制剂中进行选择，以最大限度地提高依从性。
