抗酸剂与消化性溃疡——重新评估
Antacids and peptic ulcer--a reappraisal.
作者信息
Morris T, Rhodes J
出版信息
Gut. 1979 Jun;20(6):538-45. doi: 10.1136/gut.20.6.538.
Abstract
Antacids can reduce gastroduodenal acidity for long periods if taken in substantial quantities after food. Their healing effect on gastric ulcer is minimal, if present at all, and easily overwhelmed by the benefit obtained from admission to hospital. Intensive antacid therapy appears effective in healing duodenal ulcer and preventing haemorrhage from stress ulcer, and is comparable in these respects with cimetidine but with a higher incidence of side-effects. Clinical impression strongly suggests that antacids relieve pain in peptic ulcer but objective confirmation is lacking.
摘要
抗酸剂如果在进食后大量服用，可长时间降低胃十二指肠酸度。它们对胃溃疡的愈合作用极小（即便有作用也很轻微），且很容易被住院治疗带来的益处所抵消。强化抗酸治疗似乎对十二指肠溃疡愈合及预防应激性溃疡出血有效，在这些方面与西咪替丁相当，但副作用发生率更高。临床印象强烈提示抗酸剂可缓解消化性溃疡疼痛，但缺乏客观证实。
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