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宋内志贺氏菌内毒素可降低大鼠动脉血压，但不改变大鼠垂体阿片促皮质素原的裂解及皮质酮释放。

Shigella sonnei endotoxin reduces arterial blood pressure but does not alter pituitary pro-opiocortin cleavage and corticosterone release in the rat.

作者信息

Saija A, Mondello F, Trimarchi G R, Focà A, Costa G, Mastroeni P, Caputi A P

出版信息

Res Commun Chem Pathol Pharmacol. 1984 Aug;45(2):313-6.

PMID:6091199
Abstract

Intravenous (iv) bolus injection of 320 and 640 micrograms/Kg of lipopolysaccharides (LPS) of S. sonnei (either in phase I or in phase II) resulted in a dose-dependent decrease in mean arterial pressure, when given in freely moving rats. No changes were observed in plasma beta-endorphin (beta-EP), ACTH and corticosterone levels. Pituitary beta-EP content was not modified 1 h after iv injection of LPS. Data suggest that doses of LPS, which are able to produce reversible hypotension, do not alter pro-opiocortin cleavage and corticosterone release.

摘要

在自由活动的大鼠中，静脉推注320和640微克/千克宋内志贺菌（I期或II期）的脂多糖（LPS）会导致平均动脉压呈剂量依赖性下降。血浆β-内啡肽（β-EP）、促肾上腺皮质激素（ACTH）和皮质酮水平未观察到变化。静脉注射LPS 1小时后，垂体β-EP含量未改变。数据表明，能够产生可逆性低血压的LPS剂量不会改变阿片促皮质素原的裂解和皮质酮释放。

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