Mitsuya H, Popovic M, Yarchoan R, Matsushita S, Gallo R C, Broder S
Science. 1984 Oct 12;226(4671):172-4. doi: 10.1126/science.6091268.
A recently discovered member of the human T-cell leukemia virus (HTLV) family of retroviruses has been etiologically linked to the acquired immune deficiency syndrome (AIDS). This virus, which has been designated HTLV-III, is tropic for OKT4-bearing (helper-inducer) T cells. Moreover, the virus is cytopathic for these cells. Suramin is a drug used in the therapy of Rhodesian trypanosomiasis and onchocerciasis, and it is known to inhibit the reverse transcriptase of a number of retroviruses. Suramin has now been found to block in vitro the infectivity and cytopathic effect of HTLV-III at doses that are clinically attainable in human beings.
最近发现的人类逆转录病毒T细胞白血病病毒（HTLV）家族的一个成员在病因上与获得性免疫缺陷综合征（AIDS）有关。这种病毒被命名为HTLV-III，对携带OKT4（辅助诱导）的T细胞具有嗜性。此外，该病毒对这些细胞具有细胞病变作用。苏拉明是一种用于治疗罗德西亚锥虫病和盘尾丝虫病的药物，已知它能抑制多种逆转录病毒的逆转录酶。现已发现，苏拉明在人体临床上可达到的剂量下，能在体外阻断HTLV-III的感染性和细胞病变作用。
