Mitsuya H, Matsushita S, Harper M E, Broder S
Cancer Res. 1985 Sep;45(9 Suppl):4583s-4587s.
Acquired immunodeficiency syndrome (AIDS) is a pandemic immunosuppressive disease that predisposes to life-threatening opportunistic infections and unusual forms of neoplasms. A recently discovered member of the human T-lymphotrophic virus (HTLV) family, designated HTLV-III, has been shown to be the etiological agent of AIDS. We have shown previously that a trypanosomicidal drug, suramin, can block the in vitro infectivity and cytopathic effect of HTLV-III at doses that are attainable in human beings. In the present work we report our findings that suramin can block the cytopathic effect of HTLV-III even after a defined exposure of the target helper/inducer T-cells to the virus and that the T-cells protected by suramin remain immunologically functional.
获得性免疫缺陷综合征（艾滋病）是一种大流行性免疫抑制疾病，易引发危及生命的机会性感染和罕见形式的肿瘤。最近发现的人类嗜T淋巴细胞病毒（HTLV）家族成员，命名为HTLV-III，已被证明是艾滋病的病原体。我们之前已经表明，一种杀锥虫药物苏拉明，在人体可达到的剂量下，能够阻断HTLV-III的体外感染性和细胞病变效应。在目前的工作中，我们报告了我们的发现，即即使在目标辅助/诱导性T细胞明确暴露于该病毒之后，苏拉明仍能阻断HTLV-III的细胞病变效应，并且受苏拉明保护的T细胞仍保持免疫功能。
