Eron L J, Goldenberg R I, Poretz D M
Am J Surg. 1984 Oct 19;148(4A):1-4.
The combined medical-surgical approach to therapy for osteomyelitis requires patients to receive intravenous antibiotics three to six times daily for 4 to 6 weeks after initial surgical debridement. The greatly extended half-life of the new cephalosporin, ceftriaxone (6 to 8 hours), enabled its intravenous administration once or twice daily to 76 patients for the treatment of osteomyelitis. Cure or improvement was noted in 66 of the 76 patients (87 percent). Most of the failures occurred in the group of patients with osteomyelitis complicated by vascular insufficiency. The once or twice daily dosing possible with ceftriaxone was particularly advantageous for permitting highly cost-effective at home therapy for 42 of the 76 patients.
骨髓炎的综合内科-外科治疗方法要求患者在初次手术清创后，每天接受三到六次静脉注射抗生素，持续4至6周。新型头孢菌素头孢曲松的半衰期大大延长（6至8小时），这使得76名骨髓炎患者每天只需静脉注射一到两次。76名患者中有66名（87%）病情治愈或有所改善。大多数治疗失败发生在合并血管功能不全的骨髓炎患者组中。头孢曲松每天一到两次的给药方式对于76名患者中的42名患者能够在家中进行高性价比治疗尤为有利。
