Herlin T, Eggert J, Kragballe K, Zachariae H
Arch Dermatol Res. 1984;276(5):279-82. doi: 10.1007/BF00404617.
Monocyte antibody-dependent cell-mediated cytotoxicity (ADCC) was compared to intrinsic cyclic-adenosine-monophosphate (cAMP) levels in 14 patients with systemic sclerosis. Depressed monocyte cytotoxicity was observed. Elevated cAMP levels (2-5 times) in resting monocytes were found in 5 patients; the rest had normal cAMP values. Monocyte ADCC was inversely correlated to cellular cAMP content (r = -0.6659, P less than 0.02). Scleroderma patients with high basal cAMP levels showed impaired responses to beta-adrenergic stimulation but not to prostaglandin E (PGE1) and histamine. Patients with normal basal cAMP levels showed no defect in beta-adrenergic responses. No close correlation between monocyte abnormality and clinical state was found.
对14例系统性硬化症患者的单核细胞抗体依赖性细胞介导的细胞毒性（ADCC）与内在环磷酸腺苷（cAMP）水平进行了比较。观察到单核细胞细胞毒性降低。5例患者静息单核细胞中的cAMP水平升高（2 - 5倍）；其余患者的cAMP值正常。单核细胞ADCC与细胞cAMP含量呈负相关（r = -0.6659，P < 0.02）。基础cAMP水平高的硬皮病患者对β - 肾上腺素能刺激的反应受损，但对前列腺素E（PGE1）和组胺的反应无受损。基础cAMP水平正常的患者在β - 肾上腺素能反应方面无缺陷。未发现单核细胞异常与临床状态之间有密切相关性。
