Al-Hadithy H, Isenberg D A, Addison I E, Goldstone A H, Snaith M L
Ann Rheum Dis. 1982 Feb;41(1):33-8. doi: 10.1136/ard.41.1.33.
Using a whole blood technique we assessed neutrophil migration, phagocytosis, and killing in a group of 20 patients with systemic lupus erythematosus (SLE) and in 8 patients with other connective tissue disorders. In the untreated cases of SLE neutrophil migration was significantly depressed, but it was usually normal in the treated group. This may be attributable either to an intrinsic neutrophil abnormality or to a humoral factor. Although isolated abnormalities of phagocytosis and killing were observed in SLE, these functions were normal when the patients were considered as a group. The treated patients with other collagen diseases showed enhanced migration in both autologous and control plasma, normal phagocytosis, and enhanced killing in autologous plasma only. The small group of untreated, non-SLE patients showed some depression of all 3 functions. There was no correlation between neutrophil function and clinical activity of disease. In the SLE patients there was no correlation between neutrophil function and circulating immune complexes.
我们采用全血技术评估了20例系统性红斑狼疮（SLE）患者及8例其他结缔组织病患者的中性粒细胞迁移、吞噬及杀伤功能。在未经治疗的SLE患者中，中性粒细胞迁移显著受抑，但治疗组通常正常。这可能归因于中性粒细胞内在异常或体液因子。虽然在SLE中观察到吞噬及杀伤功能的个别异常，但将患者作为一个整体时这些功能是正常的。其他胶原病的治疗患者在自体血浆及对照血浆中均表现出迁移增强、吞噬正常，仅在自体血浆中杀伤增强。一小部分未经治疗的非SLE患者的所有三项功能均有一定程度受抑。中性粒细胞功能与疾病临床活动度之间无相关性。在SLE患者中，中性粒细胞功能与循环免疫复合物之间无相关性。
