运动后正常及恶性高热易感个体中的环磷酸腺苷

Cyclic AMP in normal and malignant hyperpyrexia susceptible individuals following exercise.

作者信息

Stanec A, Stefano G

出版信息

Br J Anaesth. 1984 Nov;56(11):1243-6. doi: 10.1093/bja/56.11.1243.

DOI:10.1093/bja/56.11.1243

Abstract

Plasma cAMP concentrations were compared in normal and malignant hyperpyrexia susceptible individuals. Samples were taken before, at the peak, and at 60 and 120 min after a standardized physical stress test. It was found that, at the peak of the test, cAMP concentrations were significantly higher in malignant hyperpyrexia susceptible individuals. In addition, the return to control values was significantly prolonged in this group. The results support the hypothesis of abnormal cAMP metabolism in malignant hyperpyrexia susceptible individuals.

摘要

对正常个体和恶性高热易感个体的血浆环磷酸腺苷（cAMP）浓度进行了比较。在标准化身体应激测试前、测试峰值时以及测试后60分钟和120分钟采集样本。结果发现，在测试峰值时，恶性高热易感个体的cAMP浓度显著更高。此外，该组恢复到对照值的时间显著延长。这些结果支持了恶性高热易感个体中cAMP代谢异常的假说。