奎宁可阻断哺乳动物肠道神经元中钙激活的钾离子电导。
Quinine blocks a calcium-activated potassium conductance in mammalian enteric neurones.
作者信息
Cherubini E, North R A, Surprenant A
出版信息
Br J Pharmacol. 1984 Sep;83(1):3-5. doi: 10.1111/j.1476-5381.1984.tb10112.x.
Abstract
Quinine (100 microM) abolished the slow calcium-dependent afterhyperpolarization which occurs after an action potential in some neurones of the guinea-pig myenteric and submucous plexus. This occurred without any effect on the amplitude or time course of the action potential itself, or on the faster calcium-independent afterhyperpolarization. Tetraethylammonium did not reduce the slow afterhyperpolarization. Quinine also abolished the hyperpolarization which was evoked by intracellular injection of calcium ions.
摘要
奎宁（100微摩尔）消除了豚鼠肠肌层和黏膜下神经丛某些神经元动作电位后出现的缓慢钙依赖性超极化后电位。这一过程对动作电位本身的幅度或时程以及更快的非钙依赖性超极化后电位没有任何影响。四乙铵并未降低缓慢超极化后电位。奎宁还消除了通过细胞内注射钙离子诱发的超极化。
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本文引用的文献
1
Two types of neurones in the myenteric plexus of duodenum in the guinea-pig.豚鼠十二指肠肌间神经丛中的两种神经元。
J Physiol. 1974 Jan;236(2):303-26. doi: 10.1113/jphysiol.1974.sp010436.
2
Effects of quinine on membrane potential and membrane currents in identified neurons of Helix pomatia.奎宁对苹果螺特定神经元膜电位和膜电流的影响。
Neurosci Lett. 1981 Dec 11;27(2):139-43. doi: 10.1016/0304-3940(81)90258-5.
3
The calcium-activated potassium conductance in guinea-pig myenteric neurones.豚鼠肠肌间神经元中的钙激活钾电导
J Physiol. 1982 Aug;329:341-54. doi: 10.1113/jphysiol.1982.sp014306.
4
Calcium-activated outward current in voltage-clamped hippocampal neurones of the guinea-pig.豚鼠电压钳制海马神经元中的钙激活外向电流。
J Physiol. 1983 Apr;337:287-301. doi: 10.1113/jphysiol.1983.sp014624.
5
Effects of quinine on Ca++-induced K+ efflux from human red blood cells.奎宁对钙离子诱导的人红细胞钾离子外流的影响。
J Membr Biol. 1981 Mar 15;59(1):57-63. doi: 10.1007/BF01870821.
6
Two types of neurones lacking synaptic input in the submucous plexus of guinea-pig small intestine.豚鼠小肠黏膜下神经丛中两种缺乏突触输入的神经元。
J Physiol. 1984 Jun;351:363-78. doi: 10.1113/jphysiol.1984.sp015250.
7
Conduction and selectivity in potassium channels.钾通道中的传导与选择性
J Membr Biol. 1983;71(1-2):11-30. doi: 10.1007/BF01870671.
8
Intracellular Ca2+ activates a fast voltage-sensitive K+ current in vertebrate sympathetic neurones.细胞内钙离子可激活脊椎动物交感神经元中一种快速的电压敏感性钾电流。
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9
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J Physiol. 1981 Aug;317:67-90. doi: 10.1113/jphysiol.1981.sp013814.
10
Intracellular recording from the myenteric plexus of the guinea-pig ileum.豚鼠回肠肌间神经丛的细胞内记录。
J Physiol. 1973 Jun;231(3):471-91. doi: 10.1113/jphysiol.1973.sp010244.
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