β-肾上腺素能受体的激活刺激了神经胶质细胞中牛磺酸的释放。
Activation of beta-adrenergic receptors stimulates taurine release from glial cells.
作者信息
Shain W G, Martin D L
出版信息
Cell Mol Neurobiol. 1984 Jun;4(2):191-6. doi: 10.1007/BF00711005.
Abstract
Activation of adrenergic receptors in primary cultures of astrocytes and LRM55 glial cells stimulates taurine release. Release is inhibited by the beta-adrenergic antagonists alprenolol and propanolol but not by the alpha-adrenergic antagonist phentolamine. Receptor-mediated taurine release occurs via a specific mechanism, since efflux of other amino acids and metabolites is not affected by the beta-adrenergic agonist isoproterenol.
摘要
星形胶质细胞和LRM55神经胶质细胞原代培养物中肾上腺素能受体的激活会刺激牛磺酸释放。这种释放受到β-肾上腺素能拮抗剂阿普洛尔和普萘洛尔的抑制，但不受α-肾上腺素能拮抗剂酚妥拉明的抑制。受体介导的牛磺酸释放通过特定机制发生，因为其他氨基酸和代谢物的外流不受β-肾上腺素能激动剂异丙肾上腺素的影响。
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