Griggs D M, Chilian W M, Boatwright R B, Shoji T, Williams D O
Fed Proc. 1984 Nov;43(14):2873-7.
The importance of sympathetically mediated coronary vasoconstrictor tone as a determinant of resting coronary blood flow was assessed in the conscious dog by comparing blood flow and oxygen extraction in a normally innervated (I) and a previously sympathectomized (Sx) region of the same left ventricle. The regional ventricular sympathectomy was achieved by the topical application of phenol. The animals were well acclimated to the laboratory environment before regional myocardial blood flow was measured with microspheres or regional myocardial oxygen extraction was determined on blood sampled from chronically implanted coronary venous catheters. Results indicated that blood flow and oxygen extraction were not significantly different in I and Sx regions under these conditions. Regional blood flow data obtained after beta-adrenergic blockade or combined alpha- and beta-adrenergic blockade were not significantly different from control data. Thus we were unable to confirm previous evidence in the literature of significant resting sympathetic coronary vasoconstrictor tone in the conscious animal.
通过比较同一左心室正常神经支配区域（I）和先前已行交感神经切除术区域（Sx）的血流和氧摄取情况，在清醒犬中评估了交感神经介导的冠状动脉血管收缩张力作为静息冠状动脉血流决定因素的重要性。通过局部应用苯酚实现区域心室交感神经切除术。在用微球测量局部心肌血流或从长期植入的冠状静脉导管采集的血液中测定局部心肌氧摄取之前，动物已很好地适应实验室环境。结果表明，在这些条件下，I区和Sx区的血流和氧摄取无显著差异。β-肾上腺素能阻滞剂或α-和β-肾上腺素能联合阻滞剂给药后获得的局部血流数据与对照数据无显著差异。因此，我们无法证实文献中先前关于清醒动物存在显著静息交感神经冠状动脉血管收缩张力的证据。
