一种介导多瘤病毒DNA整合与切除的小鼠DNA序列。
A mouse DNA sequence that mediates integration and excision of polyoma virus DNA.
作者信息
Sylla B S, Allard D, Roy G, Bourgaux-Ramoisy D, Bourgaux P
出版信息
Gene. 1984 Sep;29(3):343-50. doi: 10.1016/0378-1119(84)90063-5.
PMID:6092238
Abstract
In mouse cells transformed by a temperature-sensitive polyoma virus (Py) genome, the integrated viral genome recombines with adjacent chromosomal DNA to yield a small cyclic molecule (RmI) with defined viral and cellular components. We have cloned the cellular component (Ins), determined its sequence, and examined its distribution in normal mouse DNA. The sequence of Ins displays several homologies with that surrounding the replication origin (ori) of Py or SV40 DNA.
摘要
在由温度敏感型多瘤病毒（Py）基因组转化的小鼠细胞中，整合的病毒基因组与相邻的染色体DNA重组，产生一个具有确定病毒和细胞成分的小环状分子（RmI）。我们克隆了细胞成分（Ins），确定了其序列，并检测了它在正常小鼠DNA中的分布。Ins的序列与Py或SV40 DNA复制起点（ori）周围的序列有几个同源性。
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