Desechalliers J P, Galmiche J P, Touchais J Y, Denis P, Colin R
Int J Clin Pharmacol Res. 1984;4(3):217-22.
This study compared the effects of cimetidine, ranitidine, and antacids on oesophageal pH levels. Forty-five patients were confirmed as having a gastro-oesophageal acid reflux by 3-hour postprandial metered pH measurements. The 45 patients were randomly placed into three treatment groups; one group received cimetidine 1 g/day, the second received ranitidine 300 mg/day, and the third received 60 ml/day of an antacid. The patients were retested under treatment (3-hour postprandial metered pH and prolonged 20-hour metered pH). The 3-hour postprandial metered pH was then compared to the pretreatment tests. The 20-hour postprandial metered pH test was compared with the results from 43 control (untreated) subjects with gastro-oesophageal acid refluxes. The 3-hour postprandial comparison showed a significant decrease in acid reflux with all three treatment drugs. The 20-hour measurement demonstrated a significant decrease with all three drugs in the number of acid reflux incidences compared to the untreated control patients; the ranitidine group had a significant decrease in the percentage of time with acid pH. No significant differences appeared in the comparison of the records of the 45 treated patients except for the percentage of time below pH 2 for 20 hours which was significantly lower for ranitidine. All three treatments were effective with a clear advantage in favour of ranitidine.
本研究比较了西咪替丁、雷尼替丁和抗酸剂对食管pH值水平的影响。通过餐后3小时pH值测量，45名患者被确诊为胃食管酸反流。这45名患者被随机分为三个治疗组；一组接受西咪替丁1克/天，第二组接受雷尼替丁300毫克/天，第三组接受抗酸剂60毫升/天。在治疗期间对患者进行重新检测（餐后3小时pH值测量和延长至20小时的pH值测量）。然后将餐后3小时pH值测量结果与治疗前测试结果进行比较。将餐后20小时pH值测量结果与43名患有胃食管酸反流的对照（未治疗）受试者的结果进行比较。餐后3小时的比较显示，所有三种治疗药物的酸反流均显著减少。20小时测量结果表明，与未治疗的对照患者相比，所有三种药物的酸反流发生率均显著降低；雷尼替丁组的酸性pH值时间百分比显著降低。除了雷尼替丁组20小时pH值低于2的时间百分比显著较低外，45名接受治疗的患者的记录比较中未出现显著差异。所有三种治疗方法均有效，雷尼替丁具有明显优势。
