西沙必利与西咪替丁联合治疗重度反流性食管炎：一项双盲对照试验。
Combined therapy with cisapride and cimetidine in severe reflux oesophagitis: a double blind controlled trial.
作者信息
Galmiche J P, Brandstätter G, Evreux M, Hentschel E, Kerstan E, Kratochvil P, Reichel W, Schütze K, Soule J C, Vitaux J
机构信息
Clinique des maladies de l'appareil digestif, Hôpital Guillaume et René Laennec, Nantes, France.
出版信息
Gut. 1988 May;29(5):675-81. doi: 10.1136/gut.29.5.675.
Combined treatment with cimetidine 1 g daily and cisapride 40 mg daily in patients with endoscopically diagnosed severe reflux oesophagitis was compared with single drug therapy (cimetidine and placebo). At the end of the six to 12 weeks treatment, 11 (46%) of the 24 patients under single drug therapy were endoscopically healed and three were improved. In contrast, 16 (70%) of the 23 patients under combined therapy were healed and all of the remainder were improved (p = 0.025). The severity of diurnal and nocturnal heartburn, decreased significantly more (p less than 0.05) on cimetidine + cisapride than on cimetidine + placebo. The combined treatment was well tolerated. These results suggest that combined therapy with cisapride and cimetidine may be useful in patients with severe reflux oesophagitis.
将每日1克西咪替丁和每日40毫克西沙必利联合治疗内镜诊断为重度反流性食管炎的患者与单一药物治疗（西咪替丁和安慰剂）进行比较。在6至12周治疗结束时，接受单一药物治疗的24例患者中有11例（46%）内镜检查愈合，3例病情改善。相比之下，接受联合治疗的23例患者中有16例（70%）愈合，其余患者均有改善（p = 0.025）。与西咪替丁+安慰剂相比，西咪替丁+西沙必利治疗时昼夜烧心的严重程度显著降低更多（p<0.05）。联合治疗耐受性良好。这些结果表明，西沙必利和西咪替丁联合治疗可能对重度反流性食管炎患者有用。
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