LaForce F M, Thompson B, Trow R
J Lab Clin Med. 1984 Nov;104(5):693-7.
Physical clearance is an important oral defense mechanism against gram-negative rods. We describe a simple technique that uses commercially available technetium-99m sulfur colloid to measure oral clearance. Technetium-99m sulfur colloid was sprayed into the mouth, and clearance was measured as the percent decrease in radiolabel counts over 2 hours using a radioisotope camera. Results using this technique compared favorably with clearance data using Tc-99m radiolabeled Escherichia coli. Atropine significantly decreased oral clearance rates of the colloid. Decreased clearance may be an important risk factor in the development of gram-negative rod colonization in hospitalized patients.
物理清除是抵御革兰氏阴性杆菌的一种重要口腔防御机制。我们描述了一种简单的技术，该技术使用市售的锝-99m硫胶体来测量口腔清除率。将锝-99m硫胶体喷入口腔，并使用放射性同位素相机测量2小时内放射性标记计数的减少百分比作为清除率。使用该技术获得的结果与使用锝-99m标记的大肠杆菌的清除数据相比具有优势。阿托品显著降低了胶体的口腔清除率。清除率降低可能是住院患者革兰氏阴性杆菌定植发展的一个重要危险因素。
