Barban V, Quérat G, Sauze N, Filippi P, Vigne R, Russo P, Vitu C
J Virol. 1984 Nov;52(2):680-2. doi: 10.1128/JVI.52.2.680-682.1984.
Long-term ovine fibroblast cultures contain replicative-competent lentiviruses in a latent form. This in vitro phenomenon, never described previously for lentiviruses, was clearly demonstrated by activating the expression of latent viruses with various inducing cell treatments, some of which were efficient in inducing endogenous retroviruses or latent herpesviruses. Activated lentiviruses were highly lytic in ovine fibroblasts (type I), or they established persistent infections (type II) as described previously for field isolates from sheep with progressive pneumonia (Quérat et al., J. Virol. 52:671-678, 1984).
长期培养的绵羊成纤维细胞中含有潜伏形式的具有复制能力的慢病毒。这种体外现象此前从未在慢病毒中被描述过，通过用各种诱导细胞处理激活潜伏病毒的表达得以明确证明，其中一些处理在诱导内源性逆转录病毒或潜伏性疱疹病毒方面是有效的。激活的慢病毒在绵羊成纤维细胞中具有高度溶解性（I型），或者如先前针对患有进行性肺炎的绵羊的野外分离株所描述的那样，它们建立了持续性感染（II型）（Quérat等人，《病毒学杂志》52:671 - 678，1984年）。
