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在单纯疱疹病毒1型的长重复区域中发现的串联重复DNA序列，其紧邻立即早期mRNA 1。

A tandemly reiterated DNA sequence in the long repeat region of herpes simplex virus type 1 found in close proximity to immediate-early mRNA 1.

作者信息

Rixon F J, Campbell M E, Clements J B

出版信息

J Virol. 1984 Nov;52(2):715-8. doi: 10.1128/JVI.52.2.715-718.1984.

DOI:10.1128/JVI.52.2.715-718.1984
PMID:6092697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254582/
Abstract

The 3' end of immediate-early mRNA 1 was mapped precisely within the IRL/TRL genome regions, and the DNA sequences around the 3' end were determined. An AATAAA polyadenylation signal was present 17 base pairs upstream of the 3' end, and eight tandemly repeated copies of a 16-base-pair sequence (GGGGGTGCGTGGGAGT) plus one further closely related copy were located 20 base pairs downstream. Other tandem reiterations present in the herpes simplex virus genome are described and their properties are considered.

摘要

立即早期信使核糖核酸1的3'末端被精确地定位在IRL/TRL基因组区域内，并确定了3'末端周围的DNA序列。在3'末端上游17个碱基对处存在一个AATAAA多聚腺苷酸化信号，在3'末端下游20个碱基对处有一个16碱基对序列（GGGGGTGCGTGGGAGT）的八个串联重复拷贝以及另外一个密切相关的拷贝。文中描述了单纯疱疹病毒基因组中存在的其他串联重复序列，并对其特性进行了探讨。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccea/254582/ec3ccdf6b4ac/jvirol00128-0420-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccea/254582/ec3ccdf6b4ac/jvirol00128-0420-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccea/254582/ec3ccdf6b4ac/jvirol00128-0420-a.jpg

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本文引用的文献

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The Effects of Unequal Crossing over at the Bar Locus in Drosophila.果蝇中棒眼基因座不等交换的影响
Genetics. 1925 Mar;10(2):117-47. doi: 10.1093/genetics/10.2.117.
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扩增单纯疱疹病毒1型（HSV-1）基因组的重复序列以区分临床HSV-1分离株。
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Continued expression of a poly(A)+ transcript of herpes simplex virus type 1 in trigeminal ganglia of latently infected mice.单纯疱疹病毒1型多聚腺苷酸（poly(A)）+转录本在潜伏感染小鼠三叉神经节中的持续表达。
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Expression of herpes simplex virus type 1 major DNA-binding protein, ICP8, in transformed cell lines: complementation of deletion mutants and inhibition of wild-type virus.1型单纯疱疹病毒主要DNA结合蛋白ICP8在转化细胞系中的表达：缺失突变体的互补作用及对野生型病毒的抑制作用
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8
Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture.编码单纯疱疹病毒1型立即早期蛋白ICP0的基因中的缺失突变体在细胞培养中生长受损。
J Virol. 1987 Mar;61(3):829-39. doi: 10.1128/JVI.61.3.829-839.1987.
9
The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3' termini.位于AATAAA信号下游的共有序列YGTGTTYY是有效形成mRNA 3'末端所必需的。
Nucleic Acids Res. 1985 Feb 25;13(4):1347-68. doi: 10.1093/nar/13.4.1347.
10
Detailed analysis of the mRNAs mapping in the short unique region of herpes simplex virus type 1.对单纯疱疹病毒1型短独特区域中映射的mRNA的详细分析。
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人类胰岛素基因附近的高度多态性区域由简单串联重复序列组成。
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Switch region of immunoglobulin Cmu gene is composed of simple tandem repetitive sequences.免疫球蛋白Cμ基因的转换区由简单串联重复序列组成。
Nature. 1981 Aug 27;292(5826):845-8. doi: 10.1038/292845a0.
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DNA sequences, gene regulation and modular protein evolution in the Drosophila 68C glue gene cluster.果蝇68C黏胶基因簇中的DNA序列、基因调控与模块化蛋白质进化
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Recombination within and between the human insulin and beta-globin gene loci.人类胰岛素基因座与β-珠蛋白基因座内部及之间的重组
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Simple sequences are ubiquitous repetitive components of eukaryotic genomes.简单序列是真核生物基因组中普遍存在的重复成分。
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8
A 3' co-terminal family of mRNAs from the herpes simplex virus type 1 short region: two overlapping reading frames encode unrelated polypeptide one of which has highly reiterated amino acid sequence.来自单纯疱疹病毒1型短区域的一个3' 共末端mRNA家族：两个重叠阅读框编码不相关的多肽，其中一个具有高度重复的氨基酸序列。
Nucleic Acids Res. 1984 Mar 12;12(5):2473-87. doi: 10.1093/nar/12.5.2473.
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The junctions between the repetitive and the short unique sequences of the herpes simplex virus genome are determined by the polypeptide-coding regions of two spliced immediate-early mRNAs.单纯疱疹病毒基因组中重复序列与短独特序列之间的连接由两种剪接的立即早期mRNA的多肽编码区决定。
J Gen Virol. 1984 Mar;65 ( Pt 3):451-66. doi: 10.1099/0022-1317-65-3-451.
10
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EMBO J. 1983;2(11):1953-61. doi: 10.1002/j.1460-2075.1983.tb01684.x.