O'Morchoe C C, Jarosz H M, Holmes M J, O'Morchoe P J
Lymphology. 1977 Dec;10(4):204-8.
Water diuresis was induced in dogs, under chloralose anesthesia, by hypotonic volume expansion of 5 to 10% body weight. The average diuretic response was 12.5 ml/hr/kg body weight with a urine osmolality of 175 mOsm/L. Renal hilar lymph flow and thoracic duct lymph flow increased significantly by an average of 125% and 150% respectively. The Na concentration in plasma and lymph fell by approximately 7.0 mEq/L whereas that for Cl was relatively unaffected. Control lymph to plasma ratios of approximately 1.050 for Na and 1.130 for Cl were not significantly altered even when plasma concentrations fell significantly. Urea, glucose and K concentrations were little affected. The results are consistent with the hypothesis that renal hilar lymph reflects in part the composition of the outer medullary interstitium which is directly influenced by the electrolyte pump in the ascending thick limb of Henle.
在水合氯醛麻醉下，通过向犬输入相当于其体重5%至10%的低渗液体诱导水利尿。平均利尿反应为12.5毫升/小时/千克体重，尿渗透压为175毫渗量/升。肾门淋巴流量和胸导管淋巴流量分别显著增加，平均增加125%和150%。血浆和淋巴中的钠浓度下降约7.0毫当量/升，而氯浓度相对未受影响。即使血浆浓度显著下降，钠的对照淋巴与血浆比率约为1.050，氯的对照淋巴与血浆比率约为1.130，也没有显著改变。尿素、葡萄糖和钾浓度受影响较小。这些结果与以下假设一致，即肾门淋巴部分反映了髓质外层间质的成分，而髓质外层间质直接受亨利氏袢升支粗段中电解质泵的影响。
