Chaillet P, Durand M A, Marçais-Collado H, Costentin J
J Pharmacol. 1984 Jul-Sep;15(3):375-83.
The effects of some opiates on the horizontal and vertical components of locomotor activity in mice were measured in actometers fitted with photoelectric cells counting horizontal displacements and the striding over a low partition wall. Morphine and fentanyl, used at low doses which did not modify the horizontal locomotor activity, decreased the striding over of the partition wall. Such a dissociation was not observed with either kappa or sigma agonists which affected in the same way the two components of the locomotor activity: both components were inhibited by kappa agonists and slightly stimulated by the sigma agonist SKF 10047. Although the opiate-induced inhibition of the striding over was induced by low doses of morphine, relatively high doses of naloxone were necessary for its antagonism. This apparently difficult antagonism could result in fact from the sedation which appeared when morphine was associated with naloxone.
在装有光电细胞的活动计数器中测量了某些阿片类药物对小鼠运动活动水平和垂直分量的影响，该计数器可对水平位移以及跨越低隔墙的跨步进行计数。吗啡和芬太尼在不改变水平运动活动的低剂量下使用时，会减少跨越隔墙的跨步。κ或σ激动剂未观察到这种分离现象，它们以相同方式影响运动活动的两个分量：κ激动剂抑制两个分量，而σ激动剂SKF 10047则轻微刺激两个分量。尽管低剂量吗啡可诱导阿片类药物引起的跨越抑制，但拮抗作用需要相对高剂量的纳洛酮。这种明显困难的拮抗作用实际上可能是由于吗啡与纳洛酮联合使用时出现的镇静作用所致。
