Zvartau E E, Kovalenko V S
Zh Vyssh Nerv Deiat Im I P Pavlova. 1986 Nov-Dec;36(6):1069-76.
Comparative examination of secondary-reinforcing properties of opiate agonists morphine, nalorphine, pentazocine and phencyclidine was carried out on mice using procedure of place preference conditioning in an automatic shuttle-box. Morphine, phencyclidine and pentaxocine (but not nalorphine) produced strong dose-dependent secondary-reinforcing effects. Special features of behavioural manifestations of their secondary-reinforcing action were analyzed in aspect of changes in temporal asymmetry and attendant locomotor activity of animals in the shuttle-box. On the basis of the obtained and literature data, it is suggested that mu- and sigma-opiate receptors mediate secondary-reinforcing effects of opiate agonists.
利用自动穿梭箱中的位置偏爱条件反射程序，对阿片类激动剂吗啡、烯丙吗啡、喷他佐辛和苯环己哌啶的二级强化特性进行了小鼠比较实验。吗啡、苯环己哌啶和喷他佐辛（但不包括烯丙吗啡）产生了强烈的剂量依赖性二级强化效应。从穿梭箱中动物时间不对称性变化和伴随的运动活动方面，分析了它们二级强化作用行为表现的特点。根据所获得的数据和文献资料，提示μ-和σ-阿片受体介导阿片类激动剂的二级强化效应。
