Smith R E, Morgan J H
Metab Bone Dis Relat Res. 1984;5(6):289-98. doi: 10.1016/0221-8747(84)90016-x.
Examination of bone from chickens infected as 10-day-old embryos with isolates of an avian osteopetrosis virus revealed that MAV-2(O) plaque isolate 32/2/4 caused rapid bone growth, while MAV-2(O) plaque isolate 13 caused a mild form of bone growth. MAV-2(O) plaque isolate 32/2/4 caused anemia when injected into the 8-day-old hatched chick and bone growth in ovo when injected into the 4-day-old embryo. Passive administration of neutralizing antibody protected against MAV-2(O)-induced bone growth when antibody was given to the embryo 1 day after virus. Neutralizing antibody also protected against an acute anemia observed when normal and bursectomized chickens were given MAV-2(O) 32/2/4, but antibody did not prevent the appearance of a chronic anemia or osteopetrosis in bursectomized chickens. Repeated animal passage of a slow onset plaque isolate of MAV-2(O) caused the virus to progressively induce more severe bone growth and anemia.
对10日龄胚胎感染禽骨质石化病毒分离株的鸡的骨骼进行检查发现，MAV - 2(O)蚀斑分离株32/2/4导致骨骼快速生长，而MAV - 2(O)蚀斑分离株13引起轻度骨骼生长。MAV - 2(O)蚀斑分离株32/2/4注射到8日龄出壳雏鸡时会导致贫血，注射到4日龄胚胎时会导致胚胎内骨骼生长。当在病毒感染后1天给胚胎注射中和抗体时，被动给予中和抗体可预防MAV - 2(O)诱导的骨骼生长。当正常鸡和法氏囊切除鸡接种MAV - 2(O) 32/2/4时，中和抗体还可预防观察到的急性贫血，但抗体不能防止法氏囊切除鸡出现慢性贫血或骨质石化。MAV - 2(O)的一种慢发蚀斑分离株经动物多次传代后，该病毒逐渐诱导出更严重的骨骼生长和贫血。
