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天蓝色链霉菌66中的DNA扩增与一个不稳定的精氨酸基因

DNA amplification and an unstable arginine gene in Streptomyces lividans 66.

作者信息

Altenbuchner J, Cullum J

出版信息

Mol Gen Genet. 1984;195(1-2):134-8. doi: 10.1007/BF00332735.

DOI:10.1007/BF00332735
PMID:6092842
Abstract

Streptomyces lividans 66 produced spontaneous chloramphenicol-sensitive mutants (CmlS) at a frequency of about 1% of spores. The CmlS mutant strains were very unstable, giving Arg- mutants at frequencies of about 25% of spores. All the Arg- mutants had amplified a particular 5.75 kb DNA fragment into tandem repeats of 250-500 copies per chromosome.

摘要

天蓝色链霉菌66产生自发氯霉素敏感突变体（CmlS）的频率约为孢子的1%。CmlS突变株非常不稳定，产生精氨酸缺陷型突变体的频率约为孢子的25%。所有精氨酸缺陷型突变体都将一个特定的5.75 kb DNA片段扩增为每条染色体250 - 500个拷贝的串联重复序列。

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