噬菌体λ整合酶蛋白对合成附着位点霍利迪结构的拆分
Resolution of synthetic att-site Holliday structures by the integrase protein of bacteriophage lambda.
作者信息
Hsu P L, Landy A
出版信息
Nature. 1984;311(5988):721-6. doi: 10.1038/311721a0.
Abstract
Site-specific recombination of the bacteriophage lambda genome into and out of the host bacterial genome is postulated to involve the formation of Holliday structure intermediates by reciprocal single-strand exchanges. Synthetic analogues of the predicted recombination intermediates are resolved in vitro by the protein product of the lambda int gene. Some of the structural features and reaction conditions for this genetic recombination can now be defined.
摘要
噬菌体λ基因组与宿主细菌基因组之间的位点特异性重组被假定涉及通过相互单链交换形成霍利迪结构中间体。λ int基因的蛋白质产物在体外解析了预测的重组中间体的合成类似物。现在可以定义这种基因重组的一些结构特征和反应条件。
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