Cohen M R, Pickar D, Cohen R M, Wise T N, Cooper J N
Psychosom Med. 1984 Sep-Oct;46(5):454-62. doi: 10.1097/00006842-198409000-00006.
The relationship of the endogenous opioid system and the hypothalamic-pituitary-adrenal axis to obesity was studied. Morning levels of plasma cortisol and beta-endorphin immunoreactivity in obese patients before diet treatment were found to be no different from those in matched family members of normal weight. In 32 untreated obese patients, no relationship between weight or body mass index (a measurement of obesity) and plasma levels of beta-endorphin immunoreactivity or cortisol was found. However, plasma cortisol levels were significantly correlated with obese patient ratings on the depression subscale of the General Health Questionnaire. Dexamethasone administration failed to suppress plasma beta-endorphin levels in untreated obese patients, but this finding has been reported in normal subjects in whom a similar assay methodology was used; it suppressed plasma cortisol levels in 29 of 32. The three patients resistant to suppression also suffered from benign essential hypertension. Plasma beta-endorphin immunoreactivity was unchanged, but cortisol levels significantly decreased as weight was lost on a 400-calorie/day modified protein fast. Patients who failed to complete the 6-month diet program had significantly increased plasma beta-endorphin levels compared to those who successfully completed the program.
研究了内源性阿片系统和下丘脑-垂体-肾上腺轴与肥胖的关系。发现饮食治疗前肥胖患者血浆皮质醇的早晨水平和β-内啡肽免疫反应性与体重匹配的正常体重家庭成员无异。在32名未经治疗的肥胖患者中，未发现体重或体重指数（肥胖的一种测量指标）与血浆β-内啡肽免疫反应性或皮质醇水平之间存在关联。然而，血浆皮质醇水平与肥胖患者在一般健康问卷抑郁子量表上的评分显著相关。地塞米松给药未能抑制未经治疗的肥胖患者的血浆β-内啡肽水平，但使用类似检测方法的正常受试者也有此发现；它抑制了32名患者中29名患者的血浆皮质醇水平。三名抵抗抑制的患者也患有良性原发性高血压。血浆β-内啡肽免疫反应性未改变，但在每天400卡路里的改良蛋白质禁食中体重减轻时，皮质醇水平显著下降。与成功完成6个月饮食计划的患者相比，未完成该计划的患者血浆β-内啡肽水平显著升高。
