Gialdroni Grassi G, Fietta A, Sacchi F, Derose V
Am J Med. 1984 Oct 19;77(4C):37-41.
The in vitro and in vivo effects of ceftriaxone, a newly developed cephalosporin, on phagocytes and T-cell subsets were studied. Ceftriaxone in vitro did not interfere with phagocytosis, phagocytosis-dependent metabolic activation, and microbicidal activity (against Staphylococcus aureus and Candida albicans) of human neutrophils at doses ranging from 10 to 320 micrograms/ml. In vitro chemotaxis was markedly inhibited both in the presence of and after 30 minutes of exposure to 40 micrograms/ml of ceftriaxone. Six normal adult volunteers were given 2 g of antibiotic intravenously every 24 hours for six days. The in vivo effects of ceftriaxone on neutrophil functions and T-cell subsets were investigated before and 30 minutes after injection on the first and third days. No change in any phagocyte function (chemotaxis, phagocytosis, phagocytosis-dependent metabolic activation, and microbicidal activity) or in the distribution of T-cell subpopulations was observed.
研究了新开发的头孢曲松对吞噬细胞和T细胞亚群的体外和体内作用。在10至320微克/毫升的剂量范围内，头孢曲松体外不干扰人中性粒细胞的吞噬作用、吞噬依赖性代谢激活以及杀菌活性（针对金黄色葡萄球菌和白色念珠菌）。在存在40微克/毫升头孢曲松的情况下以及暴露于该浓度30分钟后，体外趋化性均受到明显抑制。六名正常成年志愿者每24小时静脉注射2克抗生素，持续六天。在第一天和第三天注射前及注射后30分钟研究了头孢曲松对中性粒细胞功能和T细胞亚群的体内作用。未观察到任何吞噬细胞功能（趋化性、吞噬作用、吞噬依赖性代谢激活和杀菌活性）或T细胞亚群分布的变化。
