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1
Pertussis toxin blocks the inhibitory effect of muscarinic cholinergic agonists on cyclic AMP accumulation and prolactin secretion in GH3 anterior-pituitary tumour cells.百日咳毒素可阻断毒蕈碱型胆碱能激动剂对GH3垂体前叶肿瘤细胞中环磷酸腺苷积累及催乳素分泌的抑制作用。
Biochem J. 1984 Oct 1;223(1):145-9. doi: 10.1042/bj2230145.
2
Muscarinic acetylcholine receptor activation causes inhibition of cyclic AMP accumulation, prolactin and growth hormone secretion in GH3 rat anterior pituitary tumour cells.毒蕈碱型乙酰胆碱受体激活可抑制GH3大鼠垂体前叶肿瘤细胞中环磷酸腺苷的积累、催乳素和生长激素的分泌。
Biochim Biophys Acta. 1984 Sep 14;805(1):25-9. doi: 10.1016/0167-4889(84)90032-6.
3
The relationship between pertussis-toxin-induced ADP-ribosylation of a plasma-membrane protein and reversal of muscarinic inhibition of prolactin secretion in GH3 cells.百日咳毒素诱导的质膜蛋白 ADP 核糖基化与 GH3 细胞中催乳素分泌的毒蕈碱抑制作用的逆转之间的关系。
Biochem J. 1984 Nov 15;224(1):339-42. doi: 10.1042/bj2240339.
4
Pertussis toxin blocks somatostatin's inhibition of stimulated cyclic AMP accumulation in anterior pituitary tumor cells.百日咳毒素可阻断生长抑素对垂体前叶肿瘤细胞中受刺激的环磷酸腺苷积累的抑制作用。
Biochem Biophys Res Commun. 1983 Sep 30;115(3):794-9. doi: 10.1016/s0006-291x(83)80004-7.
5
Pertussis toxin treatment blocks the inhibition of somatostatin and increases the stimulation by forskolin of cyclic AMP accumulation and adrenocorticotropin secretion from mouse anterior pituitary tumor cells.百日咳毒素处理可阻断生长抑素的抑制作用，并增强福斯高林对小鼠垂体前叶肿瘤细胞中环磷酸腺苷积累和促肾上腺皮质激素分泌的刺激作用。
J Pharmacol Exp Ther. 1985 Jan;232(1):275-82.
6
Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells.细菌腺苷酸环化酶可增加垂体肿瘤细胞中的环磷酸腺苷水平及激素释放。
Biochem Biophys Res Commun. 1986 Apr 29;136(2):463-9. doi: 10.1016/0006-291x(86)90463-8.
7
Modulation of cyclic AMP accumulation in GH3 cells by a phorbol ester and thyroliberin.佛波酯和促甲状腺素释放激素对GH3细胞中环磷酸腺苷积累的调节作用
Biochem Biophys Res Commun. 1985 Jun 28;129(3):898-903. doi: 10.1016/0006-291x(85)91976-x.
8
Direct effect of adenosine on prolactin secretion at the level of the single rat lactotroph: involvement of pertussis toxin-sensitive and -insensitive transducing mechanisms.腺苷对单个大鼠催乳素细胞水平催乳素分泌的直接作用：百日咳毒素敏感和不敏感转导机制的参与
J Mol Endocrinol. 1993 Dec;11(3):325-34. doi: 10.1677/jme.0.0110325.
9
Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors.百日咳毒素可区分毒蕈碱胆碱能受体对环磷酸腺苷积累的两种衰减机制。
Proc Natl Acad Sci U S A. 1984 Sep;81(18):5680-4. doi: 10.1073/pnas.81.18.5680.
10
Regulation of GH3-cell function via adenosine A1 receptors. Inhibition of prolactin release, cyclic AMP production and inositol phosphate generation.通过腺苷A1受体调节GH3细胞功能。抑制催乳素释放、环磷酸腺苷生成和肌醇磷酸生成。
Biochem J. 1988 Oct 1;255(1):69-77. doi: 10.1042/bj2550069.

引用本文的文献

1
The relationship between pertussis-toxin-induced ADP-ribosylation of a plasma-membrane protein and reversal of muscarinic inhibition of prolactin secretion in GH3 cells.百日咳毒素诱导的质膜蛋白 ADP 核糖基化与 GH3 细胞中催乳素分泌的毒蕈碱抑制作用的逆转之间的关系。
Biochem J. 1984 Nov 15;224(1):339-42. doi: 10.1042/bj2240339.
2
Thyroliberin action in pituitary cells is not inhibited by pertussis toxin.促甲状腺素释放素在垂体细胞中的作用不受百日咳毒素的抑制。
Biochem J. 1986 Jul 1;237(1):181-6. doi: 10.1042/bj2370181.
3
Regulation of GH3 pituitary tumour-cell adenylate cyclase activity by activators of protein kinase C.蛋白激酶C激活剂对GH3垂体瘤细胞腺苷酸环化酶活性的调节
Biochem J. 1989 Sep 15;262(3):829-34. doi: 10.1042/bj2620829.
4
Measurement of intracellular mediators in enterocytes isolated from jejunal biopsy specimens of control and cystic fibrosis patients.对从对照患者和囊性纤维化患者的空肠活检标本中分离出的肠细胞内介质的测量。
Gut. 1991 Aug;32(8):893-9. doi: 10.1136/gut.32.8.893.
5
Limited accumulation of cyclic AMP underlies a modest vasoactive-intestinal-peptide-mediated increase in cytosolic [Ca2+] transients in GH3 pituitary cells.环磷酸腺苷（cAMP）的有限积累是生长激素释放激素（GHRH）介导的GH3垂体细胞胞质[Ca2+]瞬变适度增加的基础。
Biochem J. 1992 Jun 15;284 ( Pt 3)(Pt 3):637-40. doi: 10.1042/bj2840637.

本文引用的文献

1
Muscarinic receptor binding in sheep anterior pituitary.绵羊垂体前叶中的毒蕈碱受体结合
Neuroendocrinology. 1980 Jun;30(6):344-9. doi: 10.1159/000123026.
2
Acetylcholine receptors in the rat anterior pituitary gland.大鼠垂体前叶中的乙酰胆碱受体。
Endocrinology. 1980 May;106(5):1377-81. doi: 10.1210/endo-106-5-1377.
3
Muscarinic inhibition of prolactin production in cultures of rat pituitary cells.毒蕈碱对大鼠垂体细胞培养物中催乳素分泌的抑制作用。
Biochem Biophys Res Commun. 1981 Jul 30;101(2):689-96. doi: 10.1016/0006-291x(81)91313-9.
4
Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.胰岛激活蛋白。大鼠胰岛腺苷酸环化酶受体介导调节的一种修饰因子。
J Biol Chem. 1981 Aug 25;256(16):8310-7.
5
Involvement of calcium ions in dopamine inhibition of prolactin secretion from sheep pituitary cells.钙离子参与多巴胺对绵羊垂体细胞催乳素分泌的抑制作用。
Mol Cell Endocrinol. 1982 Nov-Dec;28(3):691-703. doi: 10.1016/0303-7207(82)90156-3.
6
Pertussis toxin uncouples dopamine agonist inhibition of prolactin release.百日咳毒素可消除多巴胺激动剂对催乳素释放的抑制作用。
Am J Physiol. 1983 May;244(5):E499-504. doi: 10.1152/ajpendo.1983.244.5.E499.
7
In GH3 pituitary cells, acetylcholine and vasoactive intestinal peptide antagonistically modulate adenylate cyclase, cyclic AMP content, and prolactin secretion.
Mol Pharmacol. 1983 Sep;24(2):189-94.
8
Muscarinic cholinergic inhibition of cyclic AMP formation and adrenocorticotropin secretion in mouse pituitary tumor cells.
Biochem Biophys Res Commun. 1983 Jul 18;114(1):289-95. doi: 10.1016/0006-291x(83)91626-1.
9
Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.百日咳毒素底物，即腺苷酸环化酶假定的镍成分，是一种受鸟嘌呤核苷酸和镁调节的αβ异二聚体。
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4276-80. doi: 10.1073/pnas.80.14.4276.
10
Synergistic effect of Bordetella pertussis lymphocytosis-promoting factor on protective activities of isolated Bordetella antigens in mice.百日咳博德特氏菌淋巴细胞增多促进因子对小鼠体内分离的博德特氏菌抗原保护活性的协同作用。
Infect Immun. 1983 May;40(2):523-8. doi: 10.1128/iai.40.2.523-528.1983.

百日咳毒素可阻断毒蕈碱型胆碱能激动剂对GH3垂体前叶肿瘤细胞中环磷酸腺苷积累及催乳素分泌的抑制作用。

Pertussis toxin blocks the inhibitory effect of muscarinic cholinergic agonists on cyclic AMP accumulation and prolactin secretion in GH3 anterior-pituitary tumour cells.

作者信息

Brown B L, Wojcikiewicz R J, Dobson P R, Robinson A, Irons L I

出版信息

Biochem J. 1984 Oct 1;223(1):145-9. doi: 10.1042/bj2230145.

DOI:10.1042/bj2230145
PMID:6093766
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1144274/
Abstract

The inhibition of prolactin secretion and cyclic AMP accumulation in GH3 cells by muscarinic agonists was blocked by preincubation of the cells with pertussis toxin (islet-activating protein). There was a lag of approx. 80 min in the onset of the effect on secretion. These results suggest that muscarinic agonists decrease prolactin secretion by inhibiting adenylate cyclase activity.

摘要

毒蕈碱激动剂对GH3细胞中催乳素分泌和环磷酸腺苷积累的抑制作用，可通过用百日咳毒素（胰岛激活蛋白）预孵育细胞来阻断。对分泌的影响开始出现约有80分钟的延迟。这些结果表明，毒蕈碱激动剂通过抑制腺苷酸环化酶活性来减少催乳素分泌。