百日咳毒素可阻断毒蕈碱型胆碱能激动剂对GH3垂体前叶肿瘤细胞中环磷酸腺苷积累及催乳素分泌的抑制作用。
Pertussis toxin blocks the inhibitory effect of muscarinic cholinergic agonists on cyclic AMP accumulation and prolactin secretion in GH3 anterior-pituitary tumour cells.
作者信息
Brown B L, Wojcikiewicz R J, Dobson P R, Robinson A, Irons L I
出版信息
Biochem J. 1984 Oct 1;223(1):145-9. doi: 10.1042/bj2230145.
Abstract
The inhibition of prolactin secretion and cyclic AMP accumulation in GH3 cells by muscarinic agonists was blocked by preincubation of the cells with pertussis toxin (islet-activating protein). There was a lag of approx. 80 min in the onset of the effect on secretion. These results suggest that muscarinic agonists decrease prolactin secretion by inhibiting adenylate cyclase activity.
摘要
毒蕈碱激动剂对GH3细胞中催乳素分泌和环磷酸腺苷积累的抑制作用，可通过用百日咳毒素（胰岛激活蛋白）预孵育细胞来阻断。对分泌的影响开始出现约有80分钟的延迟。这些结果表明，毒蕈碱激动剂通过抑制腺苷酸环化酶活性来减少催乳素分泌。
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1
Pertussis toxin blocks the inhibitory effect of muscarinic cholinergic agonists on cyclic AMP accumulation and prolactin secretion in GH3 anterior-pituitary tumour cells.百日咳毒素可阻断毒蕈碱型胆碱能激动剂对GH3垂体前叶肿瘤细胞中环磷酸腺苷积累及催乳素分泌的抑制作用。
Biochem J. 1984 Oct 1;223(1):145-9. doi: 10.1042/bj2230145.
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引用本文的文献
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The relationship between pertussis-toxin-induced ADP-ribosylation of a plasma-membrane protein and reversal of muscarinic inhibition of prolactin secretion in GH3 cells.百日咳毒素诱导的质膜蛋白 ADP 核糖基化与 GH3 细胞中催乳素分泌的毒蕈碱抑制作用的逆转之间的关系。
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2
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本文引用的文献
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Muscarinic receptor binding in sheep anterior pituitary.绵羊垂体前叶中的毒蕈碱受体结合
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Acetylcholine receptors in the rat anterior pituitary gland.大鼠垂体前叶中的乙酰胆碱受体。
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Muscarinic inhibition of prolactin production in cultures of rat pituitary cells.毒蕈碱对大鼠垂体细胞培养物中催乳素分泌的抑制作用。
Biochem Biophys Res Commun. 1981 Jul 30;101(2):689-96. doi: 10.1016/0006-291x(81)91313-9.
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Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.胰岛激活蛋白。大鼠胰岛腺苷酸环化酶受体介导调节的一种修饰因子。
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Involvement of calcium ions in dopamine inhibition of prolactin secretion from sheep pituitary cells.钙离子参与多巴胺对绵羊垂体细胞催乳素分泌的抑制作用。
Mol Cell Endocrinol. 1982 Nov-Dec;28(3):691-703. doi: 10.1016/0303-7207(82)90156-3.
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Pertussis toxin uncouples dopamine agonist inhibition of prolactin release.百日咳毒素可消除多巴胺激动剂对催乳素释放的抑制作用。
Am J Physiol. 1983 May;244(5):E499-504. doi: 10.1152/ajpendo.1983.244.5.E499.
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Muscarinic cholinergic inhibition of cyclic AMP formation and adrenocorticotropin secretion in mouse pituitary tumor cells.
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9
Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.百日咳毒素底物，即腺苷酸环化酶假定的镍成分，是一种受鸟嘌呤核苷酸和镁调节的αβ异二聚体。
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4276-80. doi: 10.1073/pnas.80.14.4276.
10
Synergistic effect of Bordetella pertussis lymphocytosis-promoting factor on protective activities of isolated Bordetella antigens in mice.百日咳博德特氏菌淋巴细胞增多促进因子对小鼠体内分离的博德特氏菌抗原保护活性的协同作用。
Infect Immun. 1983 May;40(2):523-8. doi: 10.1128/iai.40.2.523-528.1983.
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