Hirata K, Mogenson G J
Brain Res. 1984 Oct 29;321(1):9-19. doi: 10.1016/0006-8993(84)90676-0.
Single pulse stimulation of the sensory motor cortex of rats anesthetized with urethane was observed to inhibit the activity of neurons in the globus pallidus. When a train of 10 pulses delivered to the substantia nigra, preceded the cortical stimulation, the inhibitory response was significantly reduced in 46 of 66 globus pallidus neurons tested. A single pulse stimulus to the substantia nigra had no effect on the inhibitory response of globus pallidus neurons to cortical stimulation. Similar interaction experiments were performed in rats treated with haloperidol (HPL), a dopamine antagonist, or with 6-hydroxydopamine. In such experiments a train of stimulus pulses delivered to the substantia nigra did not attenuate the inhibitory response of globus pallidus neurons to cortical stimulation, suggesting that the observed interactions are dopamine-mediated.
观察到，对用乌拉坦麻醉的大鼠的感觉运动皮层进行单脉冲刺激，可抑制苍白球中神经元的活动。当在皮层刺激之前向黑质传递一串10个脉冲时，在所测试的66个苍白球神经元中的46个中，抑制反应显著降低。对黑质进行单脉冲刺激对苍白球神经元对皮层刺激的抑制反应没有影响。在用多巴胺拮抗剂氟哌啶醇（HPL）或6-羟基多巴胺处理的大鼠中进行了类似的相互作用实验。在这类实验中，向黑质传递一串刺激脉冲并不会减弱苍白球神经元对皮层刺激的抑制反应，这表明所观察到的相互作用是由多巴胺介导的。
