Vives F, Mogenson G J
Neuroscience. 1986 Feb;17(2):349-59. doi: 10.1016/0306-4522(86)90251-4.
The interaction of stimulation of the cerebral cortex and of the substantia nigra on the activity of neostriatal neurons was investigated in urethane-anesthetized rats. Neurons of the dorsal striatum were activated by single pulse stimulation of the sensory-motor cortex. The effects of nigral conditioning stimulation on this excitatory response of striatal neurons to cortical stimulation were studied in a series of parametric experiments in which the length of the train of pulses and the intensity of the nigral stimulation were varied. One and five pulses of nigral conditioning stimulation had little or no effect. Ten pulses of nigral conditioning stimulation reduced the excitatory response, the magnitude of the reduction being greater with higher current intensities. In another series of experiments, the effects of dopaminergic receptor antagonists on the interaction of cortical and nigral inputs to striatal neurons were studied. Sulpiride, a D2 antagonist, reversed the attenuating effects of nigral conditioning stimulation on the excitatory response of striatal neurons to cortical stimulation, whereas SCH 23390 a D1 antagonist, had no effect. The present findings support the hypothesis that the nigrostriatal dopaminergic pathway modulates the excitatory response of striatal neurons to cortical stimulation by means of dopamine D2 receptors.
在乌拉坦麻醉的大鼠中，研究了大脑皮层刺激与黑质刺激对新纹状体神经元活动的相互作用。通过对感觉运动皮层进行单脉冲刺激可激活背侧纹状体的神经元。在一系列参数实验中，研究了黑质条件刺激对纹状体神经元对皮层刺激的这种兴奋性反应的影响，其中改变了脉冲串的长度和黑质刺激的强度。一到五个黑质条件刺激脉冲几乎没有影响。十个黑质条件刺激脉冲降低了兴奋性反应，电流强度越高，降低幅度越大。在另一系列实验中，研究了多巴胺能受体拮抗剂对皮层和黑质输入到纹状体神经元的相互作用的影响。D2拮抗剂舒必利可逆转黑质条件刺激对纹状体神经元对皮层刺激的兴奋性反应的减弱作用，而D1拮抗剂SCH 23390则没有作用。目前的研究结果支持这样的假设，即黑质纹状体多巴胺能通路通过多巴胺D2受体调节纹状体神经元对皮层刺激的兴奋性反应。
