强直刺激会影响海马切片中磷酸肌醇的代谢。

Tetanic stimulation affects the metabolism of phosphoinositides in hippocampal slices.

作者信息

Bär P R, Wiegant F, Lopes da Silva F H, Gispen W H

出版信息

Brain Res. 1984 Nov 12;321(2):381-5. doi: 10.1016/0006-8993(84)90198-7.

Abstract

Tetanic but not low frequency stimulation of the perforant path in rat hippocampal slices results in changes in the metabolism of phosphoinositides and phosphatidic acid. The phosphorylation of other, non-inositol lipids was not affected by the high frequency stimulation. The observed changes in phosphoinositide metabolism are complex and biphasic, lasting at least 4 h after the termination of the tetanus. The present data support the notion that membrane phosphoinositides play a role in synaptic function.

摘要

对大鼠海马切片中穿通通路进行强直刺激而非低频刺激，会导致磷酸肌醇和磷脂酸代谢发生变化。其他非肌醇脂质的磷酸化不受高频刺激影响。观察到的磷酸肌醇代谢变化复杂且呈双相性，在强直刺激终止后至少持续4小时。目前的数据支持膜磷酸肌醇在突触功能中起作用这一观点。