DNA回旋酶拮抗剂对大肠杆菌复制后重组修复的抑制作用。

Inhibition of postreplication recombinational repair by DNA-gyrase antagonists in Escherichia coli.

作者信息

Priel E

出版信息

Cell Biol Int Rep. 1984 Sep;8(9):773-86. doi: 10.1016/0309-1651(84)90116-4.

Abstract

In the present study we investigated the possible involvement of DNA-Gyrase in postreplication repair in E. Coli. It was observed that nalidixic acid and oxolinic acid (which are known-antagonists of DNA-Gyrase) inhibited recombinational repair. These results strongly suggest that the nicking closing activity of DNA-Gyrase is essential for efficient recombinational repair.

摘要

在本研究中，我们调查了DNA解旋酶在大肠杆菌复制后修复过程中可能发挥的作用。据观察，萘啶酸和恶喹酸（已知的DNA解旋酶拮抗剂）抑制了重组修复。这些结果有力地表明，DNA解旋酶的切口封闭活性对于高效的重组修复至关重要。