21三体综合征（唐氏综合征）患者红细胞膜的ATP酶活性
ATPase activity of erythrocyte membrane in patients with trisomy 21 (Down's syndrome).
作者信息
Xue Q M, Shen D G, Dong W
出版信息
Clin Genet. 1984 Nov;26(5):429-32.
PMID:6094054
Abstract
ATPase activity of crythroyte membranes was determined in 25 cases of Down's syndrome verified by cytological and psychological examinations. The age range of the patients was 8-25 years; 16 males and 9 females. Thirty health male volunteers were selected as the control group. There was a marked reduction of total ATPase, Na+, K+-ATPase, Mg++ATPase activities and rate of ouabain inhibition in the patients with Down's syndrome. The authors suggest that there might exist transport defects in the red cell membranes in such patients.
摘要
通过细胞学和心理学检查确诊的25例唐氏综合征患者的红细胞膜ATP酶活性进行了测定。患者年龄范围为8至25岁；男性16例，女性9例。选取30名健康男性志愿者作为对照组。唐氏综合征患者的总ATP酶、钠钾ATP酶、镁离子ATP酶活性及哇巴因抑制率均显著降低。作者认为此类患者的红细胞膜可能存在转运缺陷。
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