Reavill C, Jenner P, Marsden C D
Ciba Found Symp. 1984;107:164-76. doi: 10.1002/9780470720882.ch9.
Neurons containing gamma-aminobutyric acid (GABA) are important outflow pathways from the striatum to the pallidal complex and substantia nigra. From these areas GABA-containing neurons pass to the thalamus and to various areas of the brainstem. Manipulation of GABA function in outflow zones in the rat can produce catalepsy, locomotor hyperactivity, stereotypy or circling behaviour, so mimicking the effect of altered dopamine function within basal ganglia. However, the behaviours produced by such manipulation do not form part of the animal's normal activities. Consequently manipulation of GABA action in the outflow zones of the basal ganglia may mimic extrapyramidal movement disorders more closely than the normal functions of these regions of the brain.
含有γ-氨基丁酸（GABA）的神经元是从纹状体到苍白球复合体和黑质的重要传出通路。从这些区域，含GABA的神经元通向丘脑和脑干的各个区域。操纵大鼠传出区的GABA功能可产生僵住、运动性多动、刻板行为或转圈行为，从而模拟基底神经节内多巴胺功能改变的效应。然而，这种操纵所产生的行为并非动物正常活动的一部分。因此，操纵基底神经节传出区的GABA作用可能比这些脑区的正常功能更紧密地模拟锥体外系运动障碍。
