Worms P, Lloyd K G
Naunyn Schmiedebergs Arch Pharmacol. 1980 Mar;311(2):179-84. doi: 10.1007/BF00510257.
At very low doses the GABA agonists SL 76002 and muscimol diminish haloperidol-induced catalepsy. At somewhat higher doses these compounds potentiate catalepsy. Biphasic effects on DA-receptor mediated functions have previously been noted with bicuculline and picrotoxinin. In contrast, manipulation of GABA levels by enzyme inhibition induced only a monophasic effect on dopamine-mediated behaviour. The potentiation of GABA levels by enzyme inhibition induced only a monophasic effect on dopamine-mediated behaviour. The potentiation of haloperidol-induced catalepsy by GABA mimetics is also observed with dipropylacetate, delta-aminovaleric acid and gamma-acetylenic GABA. This GABA-mimetic potentiation of catakepsy was blocked by the coadministration of bicuculline. These results confirm and extend the hypothesis that GABA-neurons influence DA neuron function. Furthermore they suggest that more than one group of GABA receptors influence directly and/or indirectly DA neuronal function, with different resultant effects.
在极低剂量时，GABA 激动剂 SL 76002 和蝇蕈醇可减轻氟哌啶醇诱导的僵住症。在稍高剂量时，这些化合物会增强僵住症。之前已注意到荷包牡丹碱和印防己毒素对多巴胺受体介导的功能有双相效应。相比之下，通过酶抑制来调节 GABA 水平对多巴胺介导的行为仅产生单相效应。通过酶抑制增强 GABA 水平对多巴胺介导的行为仅产生单相效应。用二丙基乙酸、δ-氨基戊酸和γ-乙炔基 GABA 也观察到 GABA 模拟物增强氟哌啶醇诱导的僵住症。这种 GABA 模拟物对僵住症的增强作用被同时给予荷包牡丹碱所阻断。这些结果证实并扩展了 GABA 神经元影响多巴胺能神经元功能的假说。此外，它们表明不止一组 GABA 受体直接和/或间接影响多巴胺能神经元功能，产生不同的结果效应。
