Stam H, Schoonderwoerd K, Breeman W, Hülsmann W C
Horm Metab Res. 1984 Jun;16(6):293-7. doi: 10.1055/s-2007-1014772.
Male rats were fasted for 3 days, subjected to streptozotocin-diabetes or injected with L-thyroxine, Kenacort-A40 (corticosteroid) and Synacthen (ACTH). Cardiac heparin-releasable lipoprotein lipase (LPL) activity was increased after fasting, experimental diabetes and all hormone treatments. Cardiac neutral lipase activity was decreased during diabetes and enhanced in the fasted state and by L-thyroxine, corticosteroid and ACTH administration. The close correlation between vascular LPL and tissue neutral lipase with cardiac triglyceride content is in agreement with the contention that tissue neutral lipase is similar to LPL (Hülsmann, Stam and Breeman 1982). Myocardial acid lipase activity was reduced during diabetes and L-thyroxine treatment, increased during fasting and corticosteroid administration and not affected by short-term ACTH treatment. Hepatic acid lipase activity was increased during fasting, diabetes and by L-thyroxine and reduced after corticosteroid and ACTH treatment. The alkaline liver lipase activity was depressed by fasting, experimental diabetes, corticosteroid and ACTH treatment, whereas L-thyroxine induced a slight increase in enzyme activity. The possible mechanism underlying the observed changes in acid, neutral, alkaline, and LPL activities in heart and liver are discussed.
雄性大鼠禁食3天，使其患链脲佐菌素诱导的糖尿病或注射L-甲状腺素、去炎松-A40（皮质类固醇）和合成促肾上腺皮质激素（促肾上腺皮质激素）。禁食、实验性糖尿病以及所有激素处理后，心脏肝素可释放的脂蛋白脂肪酶（LPL）活性增加。糖尿病期间心脏中性脂肪酶活性降低，在禁食状态下以及给予L-甲状腺素、皮质类固醇和促肾上腺皮质激素后增强。血管LPL和组织中性脂肪酶与心脏甘油三酯含量之间的密切相关性与组织中性脂肪酶与LPL相似的观点一致（许尔斯曼、斯坦姆和布雷曼，1982年）。糖尿病和L-甲状腺素治疗期间心肌酸性脂肪酶活性降低，禁食和皮质类固醇给药期间增加，短期促肾上腺皮质激素治疗对其无影响。禁食、糖尿病以及L-甲状腺素处理后肝脏酸性脂肪酶活性增加，皮质类固醇和促肾上腺皮质激素治疗后降低。禁食、实验性糖尿病、皮质类固醇和促肾上腺皮质激素治疗会抑制肝脏碱性脂肪酶活性，而L-甲状腺素会使酶活性略有增加。本文讨论了心脏和肝脏中酸性、中性、碱性和LPL活性变化的潜在机制。
