Crane I, Leung H, Barwick S, Parti S, Meager A
Immunology. 1984 Dec;53(4):855-9.
Jacalin, a lectin(s) extracted from the seeds of Artocarpus integrifolia (Jackfruit), was shown to induce the production of gamma interferon (IFN gamma) in human peripheral blood mononuclear cells (PBMC) and human T-lymphocyte cultures. The amount of IFN gamma produced was enhanced in the presence of mezerein, a phorbol ester derivative. Fusion of jacalin stimulated T lymphocytes with the SH9 T-cell line resulted in the formation of T-cell hybridomas which spontaneously secreted IFN gamma. The spontaneous production of IFN gamma by T-cell hybridomas was not influenced by the presence of jacalin, although significant enhancement of production was observed when the cells were cultured in the presence of mezerein.
红豆蔻凝集素是从波罗蜜（木菠萝）种子中提取的一种凝集素，已证明它可在人外周血单核细胞（PBMC）和人T淋巴细胞培养物中诱导γ干扰素（IFNγ）的产生。在佛波酯衍生物——瑞香毒素存在的情况下，所产生的IFNγ量会增加。用红豆蔻凝集素刺激的T淋巴细胞与SH9 T细胞系融合，导致形成了自发分泌IFNγ的T细胞杂交瘤。T细胞杂交瘤自发产生IFNγ不受红豆蔻凝集素存在的影响，不过当细胞在瑞香毒素存在的情况下培养时，可观察到产量显著增加。
