Takemoto T, Sakaki N, Tsuneoka K, Namiki M, Ishikawa M, Oshiba S
J Clin Gastroenterol. 1984 Oct;6(5):413-7. doi: 10.1097/00004836-198410000-00004.
We define "giant" gastric ulcer as a chronic gastric ulcer, with a diameter greater than or equal to 3 cm. Treatment of inpatients with several conventional antiulcer agents resulted in significantly lower healing rates in giant gastric ulcer than in "large" (greater than 15 and less than 30 mm diameter) or "medium" (greater than 5 and less than or equal to 15 mm diameter) ulcers. In 48 patients with giant gastric ulcers treated with ranitidine, cumulative endoscopic healing rates were: 0% after 2 weeks, 16.7% after 4 weeks, 50.0% after 6 weeks, 77.1% after 8 weeks, 85.4% after 10 weeks, and 87.5% after 12 weeks of treatment. Corresponding healing rates were determined for the control group, which included patients treated with various conventional antiulcer agents. Comparison of these results revealed that from the fourth week of treatment onward, healing rates of the ranitidine group were significantly higher than those of the control group. There was little difference in the cumulative healing rates in the ranitidine group. From these results, ranitidine is considered to be useful in the treatment of giant gastric ulcer.
我们将“巨大”胃溃疡定义为直径大于或等于3厘米的慢性胃溃疡。使用几种传统抗溃疡药物治疗住院患者时，巨大胃溃疡的愈合率明显低于“大”（直径大于15毫米且小于30毫米）或“中”（直径大于5毫米且小于或等于15毫米）溃疡。在用雷尼替丁治疗的48例巨大胃溃疡患者中，累积内镜愈合率分别为：治疗2周后为0%，4周后为16.7%，6周后为50.0%，8周后为77.1%，10周后为85.4%，12周后为87.5%。为包括使用各种传统抗溃疡药物治疗的患者的对照组确定了相应的愈合率。这些结果的比较显示，从治疗第四周起，雷尼替丁组的愈合率明显高于对照组。雷尼替丁组的累积愈合率差异不大。从这些结果来看，雷尼替丁被认为对巨大胃溃疡的治疗有用。
