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类固醇剂量对肾移植受者巨细胞病毒感染发生率的影响。

The effect of the dosage of steroids on the incidence of cytomegalovirus infections in renal transplant recipients.

作者信息

Velasco N, Catto G R, Edward N, Engeset J, Moffat M A

出版信息

J Infect. 1984 Jul;9(1):69-78. doi: 10.1016/s0163-4453(84)94576-6.

DOI:10.1016/s0163-4453(84)94576-6
PMID:6094670
Abstract

In a retrospective survey of 92 cadaver renal transplant recipients, cytomegalovirus (CMV) infections were detected in 23 of 34 (68 per cent) patients treated with high doses of steroids but in only 27 of 58 (47 per cent) patients given low doses. Pretransplant blood transfusions were associated with both an improvement in one-year allograft survival-rates (P less than 0.05) and an increase in the incidence of CMV infections. When standardised for any transfusion effect, the incidence of CMV infections was significantly higher in those patients given high doses of steroids (P less than 0.05). In the same group of patients, moreover, CMV infections were associated with a statistically significant increase in the renal allograft survival-rate (P = 0.03).

摘要

在一项对92例尸体肾移植受者的回顾性调查中,34例接受大剂量类固醇治疗的患者中有23例(68%)检测到巨细胞病毒(CMV)感染,而在58例接受小剂量类固醇治疗的患者中只有27例(47%)检测到感染。移植前输血既与一年期移植肾存活率的提高有关(P<0.05),也与CMV感染发生率的增加有关。在对任何输血效应进行标准化后,接受大剂量类固醇治疗的患者中CMV感染的发生率显著更高(P<0.05)。此外,在同一组患者中,CMV感染与移植肾存活率的统计学显著提高有关(P = 0.03)。

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The effect of the dosage of steroids on the incidence of cytomegalovirus infections in renal transplant recipients.类固醇剂量对肾移植受者巨细胞病毒感染发生率的影响。
J Infect. 1984 Jul;9(1):69-78. doi: 10.1016/s0163-4453(84)94576-6.
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Thorac Cancer. 2024 Oct;15(30):2220-2225. doi: 10.1111/1759-7714.15446. Epub 2024 Sep 14.
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Prospective cytomegalovirus surveillance in paediatric renal transplant patients.小儿肾移植患者的前瞻性巨细胞病毒监测
Pediatr Nephrol. 1993 Feb;7(1):55-60. doi: 10.1007/BF00861569.
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Unrestricted replication of human cytomegalovirus in hydrocortisone-treated macrophages.
人巨细胞病毒在氢化可的松处理的巨噬细胞中的无限制复制。
J Virol. 1991 Nov;65(11):6371-5. doi: 10.1128/JVI.65.11.6371-6375.1991.
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Cytomegalovirus infection as a complication of OKT3 therapy in kidney transplant recipients.
Ir J Med Sci. 1992 Nov;161(11):630-2. doi: 10.1007/BF02983769.
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Cytomegalovirus infection and disease after liver transplantation. An overview.肝移植后的巨细胞病毒感染与疾病。综述
Dig Dis Sci. 1992 May;37(5):673-88. doi: 10.1007/BF01296422.