Sarov I, Siqueira-Linhares M, Chardonnet Y, Levy E, Aymard M, Bosshard S, Nord E, Revillard J P
Intervirology. 1981;15(4):228-34. doi: 10.1159/000149236.
59 sera of 10 immunosuppressed renal allograft recipients who experienced recurrent cytomegalovirus (CMV) infection were analyzed by enzyme-linked immunosorbent assay (ELISA) for CMV IgA antibodies and by the complement-fixation (CF) test. A significant rise of CF titer was evident 4-53 weeks post-transplantation. 9 patients produced CMV IgA in high titers at about the time of CF antibody rise was observed. 1 patient did not produce IgA antibodies to CMV. In 3 of the 9 patients, specific CMV IgA antibodies were detected before the rise if CF titer was demonstrated. CMV IgA antibodies were found to persist for as long as 6 weeks post-transplantation. The potential application of ELISA detection of CMV-specific IgA antibodies as an early indication of CMV infection in kidney transplant patients is discussed.
对10名接受免疫抑制的肾移植受者的59份血清进行了分析，这些受者经历了复发性巨细胞病毒（CMV）感染，采用酶联免疫吸附测定（ELISA）检测CMV IgA抗体，并通过补体结合（CF）试验进行检测。移植后4 - 53周，CF滴度显著升高。9名患者在观察到CF抗体升高时产生了高滴度的CMV IgA。1名患者未产生针对CMV的IgA抗体。在9名患者中的3名中，如果证明CF滴度升高，则在其升高之前检测到特异性CMV IgA抗体。发现CMV IgA抗体在移植后可持续长达6周。讨论了ELISA检测CMV特异性IgA抗体作为肾移植患者CMV感染早期指标的潜在应用。
