Lehmann M, Schmid P, Bergdolt E, Jakob E, Spöri U, Keul J
Klin Wochenschr. 1984 Oct 15;62(20):992-5. doi: 10.1007/BF01728430.
Alpha-adrenoreceptors were determined as an equivalent to 3H-dihydroergocryptine (DHE) specifically bound on intact thrombocytes in five untrained volunteers (I), eight non-staticly trained sportsmen (II), and eight intensively staticly trained athletes (III). Bmax was 933 +/- 363 (I), 982 +/- 373 (II), and 1796 +/- 539 fmol DHE X 10(-9) thrombocytes (III). KD was 1.28 +/- 0.49 (I), 2.94 +/- 1.12 (II), and 3.58 +/- 1.07 nmol X l-1 (III). The number of binding sites per cell amounted to 561 +/- 202 (I), 589 +/- 224 (II), and 1078 +/- 323 (III). The thrombocytes of the staticly trained athletes showed a significantly higher number of binding sites and a slightly higher affinity (KD) than the other groups (p less than 0.01). However, a wide range of overlapping has to be considered. The biologic significance of these results and their transferability to other organs are open at present. It is the question whether an altered adrenoreceptor density may be one factor of a higher prevalence of hypertension in staticly trained athletes on which our research group has reported recently.
在五名未经训练的志愿者（I组）、八名非静力性训练的运动员（II组）和八名高强度静力性训练的运动员（III组）中，测定了α-肾上腺素能受体，其相当于特异性结合在完整血小板上的3H-二氢麦角隐亭（DHE）。Bmax分别为933±363（I组）、982±373（II组）和1796±539 fmol DHE×10⁻⁹个血小板（III组）。KD分别为1.28±0.49（I组）、2.94±1.12（II组）和3.58±1.07 nmol×l⁻¹（III组）。每个细胞的结合位点数分别为561±202（I组）、589±224（II组）和1078±323（III组）。与其他组相比，静力性训练运动员的血小板显示出显著更多的结合位点和略高的亲和力（KD）（p＜0.01）。然而，必须考虑到存在广泛的重叠情况。目前这些结果的生物学意义及其向其他器官的可转移性尚不清楚。我们的研究小组最近报道了静力性训练运动员中高血压患病率较高，肾上腺素能受体密度改变是否可能是其中一个因素，这仍是一个问题。
